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ÎÄÕ·¢ÐÄÇé¿ö£º

ÆÚ¿¯Ãû³Æ£ºAnnals of Neurology

ÎÄÕÂÌâÄ¿: Lecanemab-associated amyloid-¦Â protofibril in cerebrospinal fluid correlates with

biomarkers of neurodegeneration in Alzheimer¡¯s disease (Cerebrospinal fluid (CSF) lecanemab-associated amyloid protofibril concentrations correlate well with neurodegenerative biomarkers in AD)

×÷Õß: Moeko Noguchi-Shinohara, Kazuyoshi Shuta, Hidetomo Murakami, Yukiko Mori, Junji Komatsu, Chizuru Kobayashi, Steven Hersch, Kanta Horie, Kenjiro Ono

Ðû²¼ÈÕÆÚ£ºJanuary 6, 2025 (US Eastern Standard Time).

DOI: 10.1002/ANA.27175

 

ÐÅÏ¢ÁªÂ磺

¡ö Regarding research content

Kanazawa University

Professor Kenjiro Ono

TEL: +81-(0)76-265-2292

Email: onoken@med.kanazawa-u.ac.jp

Associate Professor Moeko Shinohara

TEL: +81-(0)76-265-2292

Email: m-nohara@med.kanazawa-u.ac.jp

Eisai Co., Ltd.

Kanta Horie

E-mail: kanta_horie@eisai.com

¡ö Public Relations Officer

General Affairs Section, General Affairs Division, Medical, Pharmaceutical and Health Sciences

Administration Department, Kanazawa University

Rina Yamada

TEL: +81-(0)76-265-2109

E-mail: t-isomu@adm.kanazawa-u.ac.jp

Eisai Co., Ltd. PR Department

TEL: +81-(0)3-3817-5120

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[1] V?lim?ki T, et al.Different Trajectories of Depressive Symptoms in Alzheimer’s Disease Caregivers – 5-Year Follow-Up.V?lim?ki T, et al. Clin Gerontol. 2024 Jan-Dec.PMID 36062842

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  1. Korean dementia observatory 2022: National Institute of Dementia (Korean)
  2. Korean dementia observatory 2021: National Institute of Dementia (Korean)
  3. Amin L, Harris DA. A¦Â receptors specifically recognize molecular features displayed by fibril ends and neurotoxic oligomers. Nat Commun. 2021;12:3451. doi:10.1038/s41467-021-23507-z
  4. Ono K, Tsuji M. Protofibrils of Amyloid-¦Â are Important Targets of a Disease-Modifying Approach for Alzheimer’s Disease. Int J Mol Sci. 2020;21(3):952. doi: 10.3390/ijms21030952. PMID: 32023927; PMCID: PMC7037706.

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1.Foley KE and Wilcock DM (2024). Three major effects of APOE¦Å4 on A¦Â immunotherapy induced ARIA. Front. Aging Neurosci. 16:1412006. doi: 10.3389/fnagi.2024.1412006

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1. Oki R, et al. Efficacy and safety of ultrahigh-dose methylcobalamin in early-stage amyotrophic lateral sclerosis a randomized clinical trial. JAMA Neurol. 2022;79(6):575-583.2. Japan Intractable Diseases Information Center, Amyotrophic lateral sclerosis (ALS), Designated intractable disease (2). https://www.nanbyou.or.jp/entry/52. Last accessed: September 2024. (Japanese only)

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1. Furuse J. et al. Pivotal single-arm, phase 2 trial of tasurgratinib for patients with fibroblast growth factor receptor (FGFR)-2 gene fusion-positive cholangiocarcinoma (CCA). 2024 ASCO Gastrointestinal Cancers Symposium;

Abstract No. 471. https://ascopubs.org/doi/pdf/10.1200/JCO.2024.42.3_suppl.471

2. AmoyDx? FGFR2 Break-apart FISH Probe Kit Approved as Companion Diagnostic for Eisai¡¯s Tasurgratinib in Japan.

Available at: https://www.amoydiagnostics.com/about/press-releases/245 Last accessed: September 2024.

3. Latest statistics, Cancer Information Service, National Cancer Center, Japan. (Japanese only)

4. The 23rd Follow-up Survey Reports for Primary Liver Cancer Cases in Japan (2014-2015), 2023. (Japanese only)

5. Arai Y. et al., Fibroblast growth factor receptor 2 tyrosine kinase fusions define a unique molecular subtype of cholangiocarcinoma, Hepatology, 2014, 59, 1427-1434.

6. Maruki Y. et al., Molecular detection and clinicopathological characteristics of advanced/recurrent biliary tract carcinomas harboring the FGFR2 rearrangements: a prospective observational study (PRELUDE Study), J Gastroenterol. 2021; 56(3), 250-260.

7. Tsujie M. et al., Fibroblast growth factor receptor 2 (FGFR2) fusions in Japanese patients with intrahepatic

cholangiocarcinoma, Jpn J Clin Oncol. 2021; 51(6): 911-917.

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